Tsakiris's new book, Why Science is Wrong...About Almost Everything, is largely a collection of excerpts from interviews from Skeptiko. Although the title of the book targets "science" as what's wrong about almost everything, I think Tsakiris really ends up targeting "materialism" or "scientific materialism" as what's really wrong. Science is essentially a method of systematic empirical study, and that method--properly understood--has no vested interest in what turns out to be true (or possibly true). By contrast, materialism is a global philosophical position or paradigm. As such, materialism definitely has a vested interest in what is (or can be) true. That is, materialism is a universal claim about all of reality: specifically, materialism claims that all of reality is completely reducible, without remainder, to "matter in motion." One candid advocate of this view is Alex Rosenberg who wrote in The Atheist's Guide to Reality (2011) the following:
"All the processes in the universe, from atomic to bodily to mental, are purely physical processes involving fermions and bosons interacting with one another" (p.21).